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How Long Does It Take Tramadol 50mg to Work For Pain?

How Does Tramadol Work

How Does Tramadol 50mg Work?

Pain is often described as an uncomfortable sensation that affects both the body and mind as well. It stems from the activation of nociceptors that detect tissue damage. The sensation can range from a slight annoyance to completely debilitating discomfort. In the case of debilitating pain, patients are advised to buy strong painkillers, such as Tramadol 50mg pills (Ultram), to help reduce the painful sensations. If you are wondering, what is Tramadol 50mg and how does it work - it is a synthetically based opioid treatment that is well-known for its potent painkilling properties. The tablet is used to treat moderate to moderately severe pain, and can be used in acute and chronic pain management. It has a unique composition, paired with an equally distinctive mechanism of action, and this is the primary reason behind the tablet's analgesic effects. Unlike other medical treatments that work singularly, this tablet divides itself into two parts, and this creates pain-relieving effects by acting in two different ways. This is referred to as a dual-acting mechanism of action (MOA). Both these MOA's work in corresponding manners to ultimately elevate the medications core abilities. Below is a detailed explanation of how these MOA's produce their analgesic effects: 

  • Once ingested, this medicine binds weakly to mu-opioid receptors, found in the spinal cord and brain. This low-strength attachment stops painful sensations from being properly deciphered, which subsequently leads to dulled sensations.
  • This painkiller also produces inhibitory effects by targeting the neurotransmitters, norepinephrine and serotonin. These neurotransmitters work together, with opioid actions, to provide patients with a high level of analgesia. By affecting these neurotransmitters, the body also becomes more accepting of the treatment, which ultimately reduces the possibility of side effects.

How Long Does It Take for Tramadol 50mg to Work?

  • Prescription painkillers are one of the most powerful medicines on the market today. Their innate ability to convene and alter the transmission of pain signals is an intricate process that only a potent and safe substance can carry out. Tramadol 50mg painkillers fit the bill in both respects, as they possess an equally balanced efficacy and safety profile.
  • Tramadol 50mg comes in two variations, namely immediate and extended-release. The immediate-release form of the tablet works shortly (30-60 minutes) after ingestion, thus its name. The immediate-release form is typically used in short-term treatment plans for pain (that is mild and acute pain).
  • On the other hand, when you use the extended-release form of Tramadol 50mg for pain, this formulation works at a much slower pace. This tablet uses a ratio release formula, and works by releasing 25% of the initial dose 2 hours after ingestion, and the remaining 75% over 24 hours.
  • The extended-release tablet can only be taken once a day and has similar efficacy to an immediate-release tablet, taken twice daily. This form is used to treat moderate to severe types of pain that stem from chronic conditions. It provides a high level of around-the-clock pain relief.
  • Both these forms of Tramadol 50mg essentially produce the same effects, with different durational time frames. These pills can also be used in conjunction with non-opioid based pain relievers, such as paracetamol. The combination can provide patients with a higher level of pain relief.

How Long Does Tramadol 50mg Last?

This medication is versatile in many ways, from its mechanism of action to its effects. The tablet has distinguishable characteristics, which is the main reason why patients buy Tramadol 50mg online. One of these distinguishable characteristics is the pills durational effects. Unlike other pain relievers with standard effect timeframes, Tramadol 50mg's effects vary depending on the form being used. As mentioned earlier, this tablet comes in two forms, immediate and extended-release. Although these formulations have the same active ingredient and produce the same effects, the structure of each differs slightly to accommodate their purpose. 

  • Immediate release: A single dose of this tablet produces 4 to 6 hours of analgesic effects. This timeframe is often ideal for patients who are suffering from short-term conditions.
  • Extended-release: A single dose of this tablet can last a full day - 24 hours. This timeframe best suits those with chronic conditions.

How Well Does Tramadol 50mg Work?

  • In 1998, this pain treatment became the most used centrally-acting painkiller around the world, even outselling the popular opioid, morphine. The tablet's success is primarily due to its favourable efficacy and side effect profile, which differs significantly from other medications in its class.
  • The tablet has a dose-dependent efficacy rate that lies firmly between that of codeine and morphine. Its potency is comparable to pethidine. The pills oral bioavailability is relatively high (85-100%), which permits easy conversion from the oral to the parenteral route and vice versa. The treatment's efficacy is not associated with any Tramadol 50mg side effects or severe opioid adversities.
  • Studies have confirmed the efficacy and safety of the treatment over a wide range of pain-inducing conditions that were both acute and chronically based. This combination of safety and efficacy has made the pill an ideal addition to the analgesic class of medicines.

How Long Does Tramadol 50mg Stay In Your System?

The medical world is made up of several medicinal treatments that are used to manage, control or treat illnesses. As large as the variety of medication is, so too is the variation in duration of effects and more. When taking painkillers, like Tramadol 50mg, patients are generally concerned about how long the compound stays in the body. The amount of time it takes the body to remove a therapeutic compound depends on several factors which lie beyond the specific medication type. These factors include: 

  • The presence of other medication in the body
  • Incidence of medical conditions, such as kidney problems
  • Dose being taken
  • Administration method
  • Age
  • Sex
  • Weight

Due to these factors, the same Tramadol 50mg dosage taken by one person might have a slightly different effect on another. Once this strong painkiller is consumed, the body begins to metabolise it to facilitate a clean elimination process however, this process does not happen instantly. This means that traces of the compound are still present in the body long after the tablet's initial effects have passed. Tramadol 50 mg remains in the blood, urine, saliva and hair for varying lengths of time. Below are a set of detection timeframes that tell you how long the tablet lasts, in different parts of the body, after a dose is consumed: 

  • Blood: up to 48 hours
  • Urine: 24 to 72 hours
  • Saliva: up to 48 hours
  • Hair: 30 to 90 days

As well as the strongest painkillers on the market, we also sell a wide range of strong sleeping pills and anxiety medication at without a prescription! If you have any questions, please contact us for an informative reply. We look forward to helping you with a pain relief option.


At we sell more than just painkillers . People suffering from insomnia and anxiety can select from a wide range of muscles relaxantssleeping tablets and anti-anxiety medication. All medication sold on our website is available without a doctor's prescription and delivery to any location in the USA takes just 2 to 4 working days.


Latest News for Patients Our blog provide customers with all the up to date news and information related to medication for people who are suffering from insomnia, pain, or anxiety.

Keep up to date with all the latest news and views via our blog section. Our blogs are regularly updated and provide information on the best sleeping pills medication including Ambien and Zolpidem. Information on anxiety medication treatments such as Xanax as well as our selection of strong pain relief medication including Tramadol and Hydrocodone as well as our selection of strong muscles relaxer including Soma and Carisoprodol.

Updated by Admin: December 21, 2021

Cindy Walker – Apr 14, 2021
Hi Sarah I have read a number of your blogs but this is my first time to comment. Thanks to your blogs I have now been able to make an educated choice, treat my condition and get my life back on track. Many thanks Cindy Walker

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