Tapentadol is an analgesic, or pain pills, used to treat moderate to severe pain. It works by altering the way we feel pain by affecting the central nervous system. As an opioid, it is often used when over the counter medications such as paracetamol and ibuprofen do not work. Further to this, due to how effective it is, it is often recommended when weaker, more commonly prescribed opioids such as Tramadol are not strong enough to fully treat the pain. This medication is unique in that it is the "first new molecular entity of oral centrally acting analgesics" for 25 years that has been approved for medical use.
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The most well-known brand of Tapentadol is called Nucynta, although it is also marketed under other names. Nucynta is available in two versions, the regular form, and the extended-release version, which is used for long-term, constant pain. In USA, you will find that it is marketed under the name Palexia. Tapentadol was discovered by the large pharmaceutical company Grünenthal in the late 1980's, the same company that discovered the popular painkiller Tramadol in 1962. In 2003 the company worked with Johnson & Johnson (one of the largest medical companies in the world, with a better credit rating than the United States government), to develop and market the medication. They were initially granted the rights to sell Tapentadol in the United States, Canada, and Japan, but this was later expanded to 80 other countries. In 2008 it received approval for use to treat pain by the Food and Drug Administration. It is now marketed and sold in the United States by Collegium Pharma.
Tapentadol is used to treat pain conditions that are not affected by other first line pain pills. It is used for a range of conditions, but only generally prescribed for pain that could be described as moderate to severe. Some doctors like to judge pain by providing the patient with a pain scale, which assists them in describing the severity of their pain, and therefore allows the doctor to make correct decisions in which medication to prescribe the patient. The numbers on the pain scale appropriate to take Tapentadol for are:
Moderate Pain - This type of pain can be ignored for a period of time if distracted by an activity, but it may make it difficult to concentrate fully.
Moderately Strong Pain - This type of pain can be ignored for up to several minutes at a time. Social activities and work can be done but will require more effort than normal.
Strong Pain - This type of pain interferes with your ability to work or complete normal activities.
Severe Pain - This type of pain significantly limits your ability to socialise or work. You may have difficulty sleeping.
Intense Pain - Any level of physical activity is very difficult, and you may be unable to easily hold a conversation.
Any pain levels below the above can be treated with over-the-counter medications such as paracetamol, ibuprofen or even co-codamol. Anything above you should be seeking immediate medical attention, as you will need access to pain medication which is stronger than Tapentadol.
In relation to the conditions that this medication treats, one of the more common ones is musculoskeletal issues. It is estimated that roughly 50% of the population will suffer from some type of musculoskeletal pain for longer than three months at some point in their lives. This is known as chronic musculoskeletal pain. Studies found that a proportion of people who were suffering from this type of pain and taking Tapentadol, experienced a 50% reduction in the severity of their pain.
Another condition that it has been found to be effective in treating and has been approved for use by the Food and Drug Administration, is neuropathic pain caused by Diabetes. Neuropathic pain is pain that affects the nerves in our body, and so cannot only cause pain, but also issues with sensation and movement as well. It has been found to affect at least a third of people who suffer from Diabetes, hence why so many of them buy Tapentadol in USA. Scientists believe that Diabetes-induced neuropathy is caused by uncontrolled high blood sugar levels over lengths of time, which damages the nerves. It also weakens capillaries which supply the blood vessels with nutrients.
Aside from the above, this effective and versatile medication can be useful to treat a range of conditions where moderate to severe pain is present.
If you are looking to buy tapentadol 50 mg online overnight in USA, you will likely want to understand how it affects you first after you take this medication. After taking a tablet, the medication works by binding to opioid receptors in our central nervous system (our brain and spinal cord), which affects the way we experience pain, by reducing it. Opioid receptors work in the same way whether stimulated by opioids generated in the body, such as endorphins, or outside the body, like synthetic opioids such as Tapentadol.
Neurons, also known as nerve cells, travel from the central nervous system to the peripheral nervous system, which is the network of nerves located throughout the body. Receptors located on the skin which detect pain are called nociceptors, and the signals that travel from the nociceptors to the central nervous system travel along a type of nerve called 'C fibres'. Receptors on the skin which detect touch, such as Pacinian corpuscles, transmit their signals to the central nervous system via 'A B fibres'. The difference between these two receptors and fibres is that when the touch stimulus such as touching your hand, stops, the perception of touch also stops. But when the pain stimulus stops, such as you move your hand away from something hot, the 'C fibres' keep transmitting signals, and therefore you keep receiving the sensation of pain. When the opioid medication such as Tapentadol binds to the receptors, it increases your threshold to pain, as well as reducing the transmission of the signals, thereby providing effective pain relief.
When deciding which medication they should be taking for their pain, people often ask us which we would recommend regarding Tapentadol vs Tramadol. The truth is, it really is dependent on the individual, as some prefer the former while others prefer the latter. Tapentadol is actually very similar to Tramadol, as it is an opioid that works in a similar manner. It was discovered and manufactured by the same company that discovered and manufactured Tramadol, Grünenthal, who are known for the various pain-relieving medications that they develop. One main difference between the two medications is that Tapentadol capsules are far more potent that Tramadol capsules. In addition to this, it has been noted that Tapentadol also produces less drowsiness and less vomiting than Tramadol does. Due to these points, people often prefer to buy Tapentadol.
The usual Tapentadol dosage is one tablet, every 4-6 hours for chronic pain. Once taken, the effects of the tablet should start to be felt after around 30 minutes. The half-life of this medication is around 4 hours. This means that it takes approximately 4 hours before half of the medication is eliminated from the body. However, there are different factors that can affect how quickly this medication is processed in the body:
Age - generally elderly people process medications slower than younger people, as their organ function is not as efficient. Additionally, it is likely that they are taking other medications, which may slow the processing of this medication.
Body mass - those with a higher body mass will find that this medication will be processed slower than those with a lower body mass. Additionally, they may require larger doses for them to feel the same effects.
Metabolic rate - those with a higher metabolic rate will process this medication quicker than those with a slower metabolic rate.
How long you have been taking Tapentadol - like with any medication, the longer you take it, the more likely it is that you build a tolerance to it. Those who are new to taking this medication will require a lower dose than those who have been taking it over a longer period of time.
Reduced Liver Function - Tapentadol is metabolized via the liver, therefore those with a lower hepatic function will find that they will process it slower than those with perfect liver function.
In relation to how quickly it is detectable in the body, it has been found that it is undetectable in blood after approximately 24 hours, is undetectable in urine after approximately 72 to 96 hours but is potentially detectable in the hair for up to 90 days after the last dose.
The standard starting Tapentadol dosage is 50 mg. Each dose should be swallowed whole alongside a glass of water. It is important that no more than 600 mg of this medication is taken daily, unless specifically instructed by a medical professional. You can take this medication with or without food, however, you should ensure that this stays consistent, as taking Tapentadol alongside food can slow the absorption into the body. You should ensure that you take Tapentadol capsules no longer than strictly necessary. Your doctor will be able to advise the length of this.
If you forget to take a dose, it is highly likely that your pain will return. Please ensure that you do not take two doses to account for this, as it will increase the risk of side effects.
Tapentadol is known for having a particularly low incidence of side effects in relation to other similar opioid-based medications, despite how effective it is at treating pain. Even though any Tapentadol side effects experienced are rare, some of the more common side effects that people may suffer from are:
When taking any kind of medication, you should always strive to take it for the least amount of time possible. That is because when a medication is taken over a length of time, the body becomes used to the presence of that medication, and therefore starts to build a tolerance to it. Once that medication stops being taken, the body can potentially experience adverse effects to this, which can result in 'withdrawal symptoms'. Fortunately, Tapentadol is not too well known for withdrawal symptoms, however it is recommended that if you stop taking this medication, you should taper off your dose, as opposed to immediately stopping.
If you find it difficult to stop taking this medication, you should refer yourself to a medical professional, who will be able to recommend a weaker medication to wean off onto. Furthermore, they may recommend different pain management techniques to allow you to treat the pain, without the use of medication at all.
It is important to be careful before you buy any medication, and this includes before you buy tapentadol online without prescription.
You should not take this medication if you fall into any of the following groups:
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